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The Signal Wire

JUST IN: The Immunity Gap Is Fueling Larger Measles Outbreaks A small decline in vaccination coverage can create a much bigger public-health problem. As of August 20, the CDC had received reports of 2,777 confirmed measles cases across 47 U.S. jurisdictions. Ninety-four percent were connected to outbreaks—already exceeding the 2,289 cases reported during all of 2025. Kindergarten MMR coverage fell to 92.4% for the 2025–2026 school year, below the 95% community-immunity target. About 280,000 kindergarteners lacked documentation showing completion of the MMR vaccine series. National averages can also hide local communities with much lower coverage. When measles reaches one of these pockets, it can spread quickly. This is not only a vaccination statistic. It is a warning about how small coverage declines can weaken community protection. Parents and caregivers can review vaccination records and speak with a healthcare provider, particularly before travel or when an outbreak is reported nearby. #Measles #PublicHealth #HealthNews #HealthyInsights

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Wireless Network for Behavioural Neuroscience (WNBN) https://pmc.ncbi.nlm.nih.gov/articles/PMC10180496/ This infrastructure enables remote, scalable, modular, and chronic high-throughput neuroscience studies. Using a custom-designed user interface and internet server for remote access, Bluetooth mesh technology for simultaneous and selective multi-control (i.e., a single remote for simultaneous and independently targeted control of spatially distributed aggregate of wireless devices), and affordable consumer hardware to enable mass deployment, the WNBN can be easily integrated into existing laboratory infrastructures at scale. Here we describe the operational concepts of the WNBN ecosystem for large scale in vivo control of freely behaving animals and provide proof-of-principle demonstrations of this ecosystem in established models of behavioural and circuit neuroscience. These approaches provide both a portable and built-in universal system that streamlines experimental workflows and enables previously untenable multiplexing of neural and behavioural manipulations. The WNBN enables perturbations in home cages and socially-interacting environments and this technology automates experimentation through a web-based schedule system. By measuring the locomotion, feeding, arousal and social behaviours of groups of mice or rats, we show that the system allows for bidirectional data transfer from readily available hardware, and that it can be used with programmable pharmacological or optogenetic stimulation. The WNBN system integrates wireless neural devices and other laboratory equipment with Bluetooth Low Energy (BLE) and Internet technologies to enable semi-automated and fully-automated behavioural studies, respectively. The wireless WNBN can either be controlled locally through BLE piconets (ad hoc network that connect the primary node and multiple secondary nodes using Bluetooth technology) using a smartphone or can be accessed globally over the Internet.

The Signal Wire

JUST IN: Ebola Outbreak Is Outpacing Response Capacity in the DRC The warning is no longer only about how quickly Ebola is spreading. It is about whether the response system can expand fast enough to contain it. The World Health Organization says approximately 5,000 cases of Ebola disease caused by Bundibugyo virus had been reported in the Democratic Republic of the Congo as of August 18. The outbreak remains a Public Health Emergency of International Concern, but WHO has not classified it as a pandemic emergency. The response-capacity gap is significant: • Approximately 1,000 treatment beds were available • An estimated 3,000 beds were needed • Only about 20% of cases were being detected through contact monitoring • Transmission had expanded from three health zones in May to 55 by August 12 • Forty-nine health zones were experiencing active transmission This is the signal: an outbreak becomes harder to control when case growth exceeds the available treatment, surveillance and contact-tracing capacity. Conflict, displacement, attacks on healthcare facilities, supply shortages and limited access to affected communities are also disrupting the response. In some affected areas, healthcare use has fallen by more than 40%. That means the consequences can extend beyond Ebola to maternal care, malaria treatment, trauma services and other essential healthcare. Uganda has ended its related outbreak after completing 42 consecutive days without a new confirmed case. No outbreak-associated cases have been confirmed in the United States, and the CDC currently considers the risk to the American public very low. The story is that public-health emergencies can accelerate when the systems responsible for detecting, treating and containing them are operating below the level the crisis demands. THE RESPONSE-CAPACITY SIGNAL: What happens when an outbreak grows faster than the system built to contain it? The Signal Wire™ — Decoded, not reported. #PublicHealth #EbolaOutbreak #